2015: Manganese OHES Showcase Symposium - Recent Advances in Health & Environmental Research on Mn

Ottawa, Canada

2015, October 14-15


The International Manganese Institute (IMnI) launched an ambitious 5-Year Plan in 2011 to cover scientific knowledge gaps regarding the impacts of manganese on human health and the environment. The 5-Year plan is now completed and has produced significant new research. These new studies were showcased at a dedicated symposium, addressing three major themes:

  • Recent Studies on Manganese
  • Manganese and Human Health
  • Manganese and the Environment


The symposium which was attended by 57 scientists, regulators, industry HSE professionals and academics primarily from the Americas was a resounding success. Eighteen different manganese-related research initiatives were presented, along with 3 panel discussions and 3 keynote speeches – one per theme.


Industry was represented by Afton Chemical Corp., Autlan, Carus Corporation, Elkem, Eramet, OFZ as well as the US lobbying association, Manganese Interest Group (MIG) and the Canadian consulting firm, Temple Scott Associates. Members of the IMnI team were also present.


From academia, representatives from the following institutions were present to hear first-hand some of the novel findings in the research developed under the OHES 5 Year Plan:

  • Albert Einstein College of Medicine, USA
  • The Hamner Institute of Health Sciences, USA
  • University of Cincinnati, College of Medicine, USA
  • University of Hasselt, Belgium
  • Catholic University of Louvain, Belgium
  • Universidad Nacional Autonoma de México (UNAM)
  • University of Ottawa, Canada
  • University of Toronto, Canada


Some of the world’s leading regulators were present to listen and share some of their ideas via presentations and panel of discussions:

  • Environment Australia
  • Health Canada
  • Environment Canada
  • US Environment Protection Agency (EPA)
  • UK Health and Safety Executive (UK HSE)
  • Public Health Slovakia


The symposium provided a forum to showcase many top rate publishable studies that will improve the understanding of manganese toxicology and possibly encourage regulators to increase the reference values derived from environmental and human health risk assessments.

Summary of presentations and discussions are below


Title Date Format Download
Symposium Proceedings Summary 23/10/15 PDF » Download
Symposium Detailed Program 18/08/15 PDF » Download
Speakers Biographies 05/10/15 PDF » Download
Keynote: A Global Portrait of the Manganese Industry - A Socioeconomic Perspective - Meg Postle, Risk & Policy Analysts, UK 02/11/15 PDF » Download
Manganese Reproductive Effects: A New Story To Tell - Doreen McGough, IMnI, France 02/11/15 PDF » Download
A New Approach to Inhalation Toxicology – The Fixed Dose Procedure - Ian Indans, Health and Safety Executive, UK 02/11/15 PDF » Download
The Complex Behavior of Inorganic Materials –The Role of Manganese Chloride in Prenatal Development - Eric Wood, Harlan Laboratories, Switzerland 02/11/15 PDF » Download
Manganese Exposure and Developmental Neurotoxicity - Cross Species Evaluation of Current Evidence - Donald Mattison, Risk Sciences International, USA 02/11/15 PDF » Download
Keynote: Setting Evidence-Based Occupational Exposure Limits for Manganese - Len Levy, Chair of Scientific Committee on Occupational Exposure Limits, European Commission (SCOEL) - via video conference 02/11/15 PDF » Download
Application of a Framework for the Selection of an Appropriate Occupational Exposure Limit - Michelle Deveau, University of Ottawa 02/11/15 PDF » Download
Challenges in Metals Risk Assessment under REACH: Lessons Learned from Manganese - Violaine Verougtraete, Eurometaux, Belgium 02/11/15 PDF » Download
US EPA’s Response to the NRC Review of the IRIS Program: Implications for Metals Risk Assessment - Vincent Cogliano, US Environmental Protection Agency, USA 02/11/15 PDF » Download
Physiologically-Based Pharmacokinetic Models for Manganese - Mel Andersen, Hamner Institute for Health Sciences, USA 02/11/15 PDF » Download
A Novel Approach to Describing U-Shaped Dose-Response Curves for Manganese Using Categorical Regression - Brittany Milton, Risk Sciences International, Canada 02/11/15 PDF » Download
Keynote: Life Cycle Analysis of Manganese and the Environment - Mohammed Ali, Hatch Limited, Canada 02/11/15 PDF » Download
The Use of Life Cycle Assessment on Addressing Environmental Issues - Josh Hendry, thinkstep, Canada 02/11/15 PDF » Download
Biotic Ligand Model for Manganese - A Collaborative Initiative with the UK Environment Agency - Adam Peters, WCA Environment, UK 02/11/15 PDF » Download
Australia & New Zealand's Water Quality Guidelines for Mn in Fresh and Marine Waters - The Way We See It - Andrew Harford, Department of Environment, Australia 02/11/15 PDF » Download
Assessing Potential Aquatic Risks of Manganese: Putting Scientific Development into Practice - Graham Merrington, WCA Environment, UK 02/11/15 PDF » Download

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